21st century medicine and emerging biotechnological syndromes: a cross-disciplinary systematic review of novel patient presentations in the age of technology

Biotechnological syndromes refer to the illnesses that arise at the intersection of human physiology and digital technology. Now that we experience health and illness through so much technology (e.g. wearables, telemedicine, implanted devices), the medium is redefining our expression of symptoms, the observable signs of pathology and the range of diseases that may occur. Here, we systematically review all case reports describing illnesses related to digital technology in the past ten years, in order to identify novel biotechnological syndromes, map out new causal pathways of disease, and identify gaps in care that have disadvantaged a community of patients suffering from these digital complaints. PubMed, MEDLINE, Scopus, Cochrane Library and Web of Science were searched for case reports and case series that described patient cases involving biotechnological syndromes from 01/01/2012 to 01/02/2022. For inclusion the technology had to play a causative role in the disease process and had to be digital (as opposed to simple electronic). Our search returned 7742 articles, 1373 duplicates were removed, 671 met the criteria for full review and 372 were included in the results. Results were categorised by specialty, demonstrating that syndromes were most common in Cardiology (n = 162), Microbiology and Infectious Diseases (n = 36), and Emergency and Trauma (n = 26). The 372 unique patient cases demonstrated a range of severity from mild (e.g., injuries related to Pokemon Go) to moderate (e.g. pacemaker-generated rib fractures) and severe (e.g. ventilator software bugs causing cardiac arrest). Syndromes resulted from both consumer technology (e.g. gaming addictions) and medical technologies (e.g. errors in spinal stimulators). Cases occurred at both the individual level (e.g. faulty insulin pumps) and at the population level (e.g. harm from healthcare cyberattacks). This was a retrospective systematic review of heterogeneous reports, written in English, which may only reflect a small proportion of true prevalence rates in the population.


Introduction
Digital technologies are reshaping our bodies, our minds and our experience of health and disease.We spend a great deal of time building these new tools, examining them, and celebrating their feats, yet we have been less attentive to the ways in which these technologies are rebuilding us.The screens we are staring into daily are reshaping our eyes [1]; our backs bend into our devices stretching our spines into new postures [2]; our minds twist to adapt new modes of information processing [3]; all the while our tapping fingers are reshaping our tendons and joints [4,5].The implantation and ingestion of digital technologies into the body has further expanded the remit of possible technology-related bodily phenomena [6][7][8][9][10][11].Our psychology and physicality are constantly in flux, moulded by our shifting environment that is evermore defined by digitisation as we carry out dual online and offline lives.
Within academia, the field of digital health has made great advances in exploring how we can use technology to improve human wellbeing.In our work, we are concerned with the reverse direction of this relationship and with the medium of technology itself.Ever since Nietzsche's contemporaries commented on his new style of writing after being forced to use a typewriter, technologists have explored the reciprocal relationship between humans and their machines-seeing that the tools we create tend to reshape our capacities as we work through them [3,12].As we increasingly experience health and illness through technology (wearables, implanted devices etc.), the medium is redefining our expression of symptoms, the observable signs of pathology, and the range of possible diseases that may occur.
In healthcare, implantable devices can malfunction manifesting as previously unseen syndromes.Our physicality becomes vulnerable to electromagnetic interference and must adapt to new biometric materials.To capture these new possibilities, we propose that "Biotechnological syndromes" should reference syndromes that emerge at the intersection of human health and technology.The term is deliberately broad to encompass cases as different as vertigo secondary to haptic-integrated virtual reality [9] and cardiac arrest due to ventilator software bugs [13].
Here we argue that the landscape of healthcare biotechnology is now so complex that digital complaints can no longer be managed as an offshoot of an existing clinical domain.We see this need manifesting across specialties-psychiatrists are responding to unusual psychological sequelae resulting from digital technologies (e.g., digital hoarding [14]), ophthalmologists are observing advanced rates myopia related to screen-use [1], and neurologists are witnessing new neuropsychiatric manifestations from errors in implanted Deep Brain Stimulators (DBS) [8,[15][16][17][18][19].Though these presentations may seem heterogeneous, the underlying mechanisms are often shared and require examination through the lens of their similarities e.g., software bugs in pacemakers may also occur in spinal stimulators.Positioning biotechnological syndromes together as a group, instead of in the margins of existing specialties, allows us to draw crossdisciplinary intelligence and examine the evolving causal pathways to disease that begin with technology and end in biology.
Biotechnological syndromes may affect individual patients (e.g.phantom shocks [7]), or groups of patients simultaneously (e.g., wireless networks impacting the integrity of ECG investigations and cardiac care [20]).Population level impact may occur in the home where patients rely on the cloud to tailor care, or within hospital settings where technological failures in drug-delivery systems can place patient life at risk [21,22].
While whole populations may be at risk, not all populations are affected equally, with biotechnological complaints being unevenly distributed amongst the population, compounding pre-existing health inequalities [23][24][25][26].For example, the gender-based differences in cybersickness related to virtual environments has been attributed to androcentric design of augmented realities [27].The way in which new technologies are created and distributed is determining how the burden of biotechnological disease falls amongst the population.

Research aim
In a comprehensive survey of case reports across the medical literature, we present a cross-disciplinary analysis of reported cases that relate to digital technology and meet the criteria of a 'Biotechnological syndrome' .We have adopted the term 'Biotechnological syndrome' , as we are concerned with issues evolving from the foundational root of Biotechnology-defined as intersection between the natural and engineering sciences [28].Hence, in our study we define a Biotechnological syndrome as clinical symptoms and signs that emerge due to interaction with technologies stemming from the natural and engineering sciences.We do not define a set of included technologies as the landscape of healthcare technology is constantly changing and such a definition would soon become redundant, instead we have defined inclusion by the underlying technical mechanisms that drive function.
Our research is also written through a clinical lens, as we are interested in the challenges healthcare professionals face when managing clinical cases that involve technological mechanisms not covered in their training (e.g.radio-communication, computer programming).The pathology that underpins a Biotechnological syndrome must therefore originate in a technology emerging at the intersection of the natural and engineering sciences, and the technology itself must play a causative role in the process of disease that manifests in a clinical presentation.As our research is focused on the last ten years, a period previously described as the 'Decade of the Internet of Things' , we expose issues associated with modern biotechnological features, such as connected intelligent medical devices and the 'Internet of Medical Things (IoMT)' [29,30].Through our evaluation of the case report literature we aim to explore the following research questions: In addressing these questions we seek to draw connections between similar biotechnological cases occurring in disconnected specialties; illuminate any current gaps in medical knowledge regarding these syndromes; and better understand these mechanisms of disease.

Data sources and searches
We searched PubMed, MEDLINE, Scopus, Cochrane Library and Web of Science for reports that described patient cases involving biotechnological syndromes in the past ten years (01/01/2012-31/12/2022), adhering to PRISMA Guidelines for systematic reviews and mirroring the methods of previous authors systematically reviewing case report literature (Fig. 1 and Supplementary A-B) [1].We were interested in digital devices (e.g., smartphones) as opposed to all electronic devices (e.g., lamps) and therefore parameterised our definition of technology.We utilise the definition of digital technologies in healthcare provided by the Food and Drug Administration (FDA), which states-"Digital health technologies use computing platforms, connectivity, software, and sensors for health care and related uses.These technologies span a wide range of uses, from applications in general wellness to applications as a medical device".In some cases it may not be possible to ascertain whether a technology was digital or simply electronic, for example in the case of e-Cigarettes.At their most basic these e-cigarettes are battery powered vaporizers of nicotinic liquid, but at their most advanced they are accompanied by connectivity features that allow them to be synced with smartphones e.g.Smokio Vapes [31].Thus, simple designs may not be considered a digital technology yet in connected models, where an app may influence inhalation frequency, the technology may affect lung disease severity.If we could not determine whether a device was purely electronic, or had digital elements, we opted to retain it for completeness.

Data extraction
One reviewer extracted data, from which all authors collaboratively reviewed the included studies and evaluated the role of the technology in the patient's clinical presentation.

Inclusion criteria
1. Study Type: A case report, case series or systematic review of cases.2. Selecting Digital Technologies: (a) We excluded anything non-electronic e.g., hip prosthesis, (b) We excluded technology that was electronic, but had no digital component (e.g., surgical diathermy tools) [29]; (c) We retained technology that was clearly digital (e.g., smartphones), and electronic technologies where the digital element could not be ascertained (e.g.e-Cigarettes).3. Disease Causal Pathway: The technology had to play a role in the causal pathway of disease, thus excluding cases where the presence of technology was incidental or unrelated.
Our results are structured under the clinical subspecialties, determined by the speciality that played the main role in patient management.Throughout the manuscript patients are referenced by age and sex e.g.50F (age 50, sex female).

Role of funding source
The research was supported by UK Research and Innovation (UKRI Grant Reference Number EP/S021612/1) who fund the doctoral research of the corresponding author.

Results
Our systematic search returned 7742 articles, from which 1376 duplicates were removed, 671 met the criteria for full text review and 372 were included in the final results.

Medical specialties
Table 1 details the number of case reports by specialty, demonstrating that digital pathologies were most common in Cardiology (n = 162), Microbiology and Infectious diseases (n = 36), and Emergency and Trauma (n = 26).There was a range of clinical severity; (i) mild e.g.soft tissue injuries related using Segway vehicles [32] (ii) moderate e.g.traumatic drone related injuries [33], explosions from electronic cigarettes [34], and (iii) severe e.g.hypoglycaemic death related to an insulin pump [35].
The most severe cases presented as life-threatening injury.One report described a low-impact virtual reality fall, which resulted in spinal cord injury [36].Nishihama and colleagues described a 65F using a sensor-augmented insulin pump for diabetes who experienced repeat dosing errors related to technological issues, culminating in sudden death due to severe hypoglycaemia [35].In paediatrics, Duff and colleagues report two cases of circulatory arrest due to failures of ventricular assist devices (VADs) [37].The authors highlight the diagnostic challenge inherent within these cases where the devices produce non-pulsatile flow rendering traditional clinical assessments (pulse and blood pressure) obsolete [37].In the sections below we divide our analysis of the clinical cases by those caused by (i) consumer technology (e.g., gaming devices) and (ii) healthcare technology (e.g., glucose sensors).

Medical specialties-consumer technology
Biotechnological syndromes may arise from our interactions with technology outside of the healthcare setting, such as injuries from tasers [38][39][40], e-Cigarettes [41,42] and exercise machines [43].Computing technologies were common culprits of these harms, such as the 64F who developed third-degree burns requiring partial foot amputation due to an overheating laptop [44].Tremaine and Avram highlighted adverse dermatological events related to energy-based devices (including lasers and radiofrequency technologies) [45].Aniruddha and colleagues report a 23 M with progressive visual loss due to laser pointer-induced maculopathy [46].Bellal and Armstrong reported injuries presenting to their trauma centre sustained secondary to gameplay with augmented realitybased applications [47].

Medical specialties -healthcare technologies
Pacemakers were the most common implanted medical technology described in the literature, with complications including: runaway pacemakers [48]; pacemaker electrical storms [49]; Reel's syndrome, Twiddler's syndrome and Ratchet Syndrome -all referring to complications arising from the displacement of wire based systems [49][50][51].Now that pacemaker technology has been extended to other domains, such as Deep Brain Stimulators (DBS) in neurology and gastric stimulators in gastroenterology [52], previously reported pacemaker complications are manifesting in the context of these new devices e.g. the neurological patient with an intrathecal baclofen pump who presented with withdrawal as a result of Twiddler's Syndrome [53].
Device malfunctions materialise differently depending on their physiological setting.DBS case reports illustrated the range of neuropsychiatric symptoms resulting from technological failures including compulsive skinpicking [16], headache [17], keyboard-typing dysfunction [15], choreiform dyskinesia and intense sadness [8].Complications of Vagal Nerve Stimulators (VNS) often presented with an aura of throat and respiratory symptoms [54] and failures of spinal cord stimulators presented with varied symptoms and signs, including tinnitus [55] and refractory sexual arousal [56].
A high number of device-related infections involved unusual pathogens: listeria bacteraemia originating from a pacemaker [57] and life-threatening implications of necrotising pulmonary aspergillosis originating from LVAD [58].Further, allergy to pacemaker compounds and infection can be hard to distinguish, as highlighted in Robledo-Nolasco's paper regarding the 17F treated with antibiotics for 18 months for a presumed pacemaker infection -only to later find this was a case of nickel rejection [59].Xu and colleagues explore this topic further and discuss 'Graft-versus-host disease' of implanted devices [60].
In hospitals, failures in drug-delivery systems are of particular concern given the increasing prevalence of cyberattacks on healthcare infrastructure [22,61].The example of pathology arising from a malfunctioning intrathecal medication system, highlights the danger that compromised drug delivery equipment poses to patients [62].Further, Faulds and colleagues describe hypoglycaemic emergencies resulting from insulin pump malfunctions [21], and patient harm can arise from malfunctions in robotic assistive technologies for surgery [63].

Surgical specialties
In the surgical specialities, biotechnological phenomena frequently materialised as Ear, Nose and Throat (ENT) complaints largely related to cochlear implants (CI) (Table 2).We encountered twelve papers focused on CI complications, uncovering (i) a 26F with facial pain, rash and dizziness [64] and (ii) a 28 M with auditory disturbance and seizures, which fully resolved following device removal [65].
In Obstetrics, the management of pregnant patients with implanted devices posed additional challenges; Patel and colleagues reported discuss the complexities of managing pain for an obstetric patient with a spinal cord stimulator requiring an urgent caesarean section [66].Further, Tang and Hyman report a 34F who developed syncope after the administration of labour epidural analgesia, thought to have interacted with her in-situ VNS [67].

Psychiatry
Table 3 provides the full list of psychiatric cases, in which there was a mixed focus on consumer and medical devices.In the consumer space, we see new manifestations of old psychiatric processes that have been transformed through technology, such as 'digitised' OCD symptoms related to online behaviour [68].Komendi and colleagues explore how excessive smartphone use can be evaluated through traditional diagnostic frameworks for  addiction [69].Sharma and Mahapatra discuss a 16 M who developed maladaptive daydreaming and internet gaming addiction following extensive cyberbullying [70].
Cases involving healthcare technologies included DBS malfunctions which frequently presented with psychological symptoms [18], however in many of these cases mental illness was a co-morbidity of the disease the DBS was treating (hence distinguishing one from the other proved challenging).Psychological effects of a technology may result from wider social effects, such as the 28 M whose LVAD was repeatedly mistaken for an explosive device and faced repeated accusations of being a "suicide bomber" [71].Al-Shaiji et al. describe the 'psychological disturbances' of three females who underwent sacral neuromodulation for lower urinary tract dysfunction [72].While the article has an unfortunate flavour of psycho-pathologising female patients, it does raise an important question of the psychological impact of these technologies.

Cross-disciplinary & public health
One challenge for practitioners is that biotechnological syndromes manifesting in their specialty, may result from a technology initiated within an unfamiliar domain.For example, (i) Refractory sexual arousal subsequent to a neurostimulator [56]; (ii) New onset tinnitus following spinal stimulator implantation [55]; (iii) Abdominal spasms resulting from pacemaker phrenic nerve stimulation [73]; (iv) Arm pain secondary to brachial plexus injury caused by impingement from a loop of ICD lead [74].
In addition, biotechnological syndromes may be hard to detect due to a confusion of cause and effect.Sommer et al. report a remarkable case in which a wheelchair bound patient with a worsening history of dysarthria, one day surprised his carer by regaining his clarity of speech and his ability to walk [75].On noting the concurrent battery depletion of the patient's DBS, it was uncovered that the symptoms that had been assigned to disease progression, in fact related to incorrect device settings.
Lastly, biotechnological syndromes may affect whole populations at a time.Hardell et al. described radiofrequency radiation from base stations causing high levels in an apartment in Stockholm, rendering the accommodation unliveable [76].Chung et al. describe the impact of a Wireless Local Area Network on ECG machines, hindering the effective evaluation of cardiac patients [20].Further, for pumps that rely on electronic programming to correctly control concentrated medications, their vulnerability to faults, EM interference and cybersecurity exploits is of paramount concern [21,35,62].
Those working in health disparities may examine the impact of digitisation on marginalised groups, for example home based telemetric medicine is dependent on signal coverage -a infrastructural necessity that correlates closely with urbanity and socioeconomic affluence [77,78].Patient's with higher body habitus may be at increased risk of device failures, as suggested by Katsaras et al. who consider the impact of body habitus on loss of telemetric device function in their 63F pacemaker-dependant patient [78].Women and girls face additional risks, particular regarding technologyfacilitated abuse, and psychiatric misdiagnosis and inappropriate treatements [25,[79][80][81][82].

Discussion
The biotechnological case reports we have identified only represent those cases thought interesting enough to write up and report in the peer-reviewed literature.The scope of true disease is likely far larger.We now turn to a series of themes that emerged from our evaluation of the case reports uncovered in our work.

Causal pathways of biotechnological syndromes
The factors present across the causal pathways of biotechnological disease included heat (linked to CPU, GPU or other device features), EM interference, connectivity features, cybersecurity vulnerabilities, software and hardware faults -all of which interacted with human physiology culminating evolving syndromes influenced by shifting technological and biological factors.In Fig. 2, we provide an illustration of the causal pathways of these biotechnological diseases, mapping these processes from their shared source pathology (e.g., software bug) to their manifestation in patient symptoms and signs.
Khan and colleagues provided a useful example of mapping the causal pathway of a biotechnological syndrome through the case of a pacemaker patient, where a software storage error resulted in inappropriate pacing inhibition, presenting as frequent episodes of light-headedness for the patient [83].In this instant, the disease pathway was: storage software bug, inappropriate pacing inhibition, poor circulatory flow and syncope.In the case of two paediatric deaths, Duff and colleagues further discuss device-related aetiologies, including drivelines and battery issues [37].
Lastly, automation appeared to be a particular concern.Dufour et al. presented a case series of patient illnesses that related to autonomous decisions taken by ventilators on an Intensive Care Unit (ICU) [13].The silent takeover of commands by the ventilator, without clinicians being made aware, manifested in complex patient pathology that the attending doctors struggled to interpret [13].

Electromagnetic interference and Electric smog
Electromagnetic (EM) interference refers to any EM field signal that can be detected by device circuitry.Dunker et al. refer to these phenomena as 'Electric smog' and describe a variety of mechanisms that attempt to resolve interference (pseudo-faraday cage, pan methods) [84].In emergencies EM interactions may be hard to avoid, such as for the 64 M who experienced tremor as a malfunction of his DBS following interference from external defibrillation performed during cardiac arrest [19].Furthermore, given the growth of the Internet of Things (IoT), the potential for EM interactions is increasing.Sources of EM interference that caused patient illness included wireless networks [20], swimming pool generators [85], water pumps [86], electrostatic discharge from fleece clothing [87], co-existing implanted devices [88], surgical equipment [89], plastic toys [90], hot tubs [91], electrical installations [92] and consumer devices such as Fitbits [93].Asher et al. describe a case of a patient's e-cigarette interacting with an implantable cardioverter-defibrillator (ICD), and a 55F with an ICD which reverted to magnet mode due to interference with the patient's fitness watch [93].Lastly, Wight et al. present a case of EM interference from electrolysis within the chlorination systems of swimming pools, uncovered in the case of a 41F whose inappropriate pacemaker shocks correlated with her time swimming in the pool [94].

End of Battery Life (EBOL) pathology
Over the next few years many devices will face battery depletion, particularly impacting neuropsychiatric patients for whom deep brain stimulation (DBS) and vagal nerve stimulation (VNS) were approved in the last two decades, and EOBL is estimated at 6-10 years [95].Pardo described the issues that neuropsychiatric patients will have as they face EOBL, exampled by the case of a middle-aged patient with bipolar disorder who relapsed following EOBL of her device-raising the question of whether neuropsychiatric device EBOL should be treated as a psychiatric emergency [95].Listening to the device vs. the patients Throughout these stories patient voices are consistently heard insisting there is something wrong with their device, to find themselves dismissed due to 'normal' findings from device interrogation.Such was the case for a pregnant patient with a cochlear implant who suffered for 8 months complaining of dizziness, facial twitches, and pain, only to be informed that the cause was not the device as there was no malfunction picked up on external testing [64].The source wasn't found until later on during a surgical procedure, when a tear along the electrode coating was identified and the electrode was found pressed up against the facial nerve [64].Our understanding of emerging technologies is constantly advancing, and we do not currently have the research knowledge, clinical training or investigations required to provide all the answers when the technology goes wrong.It is imperative therefore that the patient perspective takes precedent, and that their subjective experience is not treated secondary to device interrogations which may not capture all relevant information [64].Given that previous research has demonstrated that the unconscious biases of clinicians tend fall along lines of gender, class, and race, it will be important to explore how device issues are managed through a lens of health equity [23-25, 27, 82].

Research & training
Each case in this review warrants consideration if we are to understand these illnesses better.With each new agent we have introduced to the body, we have potentiated a range of syndromes that have not existed before.In several cases, we discussed the challenges of differentiating device-related symptoms from disease-related phenomena.Devices are placed local to the anatomical region central to the disease process, thus their malfunctions may mimic the underlying disease process.Through effective research we may learn to distinguish between the device pathology and disease pathology, and ensure patients are correcting diagnosed and supported.

Digital updates to clinical assessments
Technological features should be incorporated into each stage of the patient journey.During history taking, clinicians would benefit from knowing the characteristic symptoms and auras of device failure, such as the respiratory symptoms described by patients experiencing VNS failures [96].We have uncovered clinical signs specific to technology, which would be useful in clinical examination (e.g. a 26F where the positive Tinel's sign over the ICD generator helped inform a diagnosis of brachial nerve injury secondary to ICD impingement [74]).Risk factors for digital diseases may also be helpful to identify and signpost e.g.manual labour occupations may increase likelihood of Reel syndrome and pacemaker malfunction.Lastly, at present clinicians are limited in the investigations they can use to evaluate biotechnological syndromes, highlighted in a report of a malfunctioning DBS where the presence of largely normal blood tests and imaging demonstrated that hardware faults may not be captured by standard physiological investigations [8].

Digital updates to post-mortems
Presently, we do not have a clinical surveillance system for tracking biotechnological deaths.In 2022 The United Kingdom Royal College of Pathologists (RCPath) produced guidelines on autopsy practice, offering tailored recommendations on post-mortems that involve an implanted medical device [97].While an excellent move in the right direction, many death certificates are not completed by pathologists-it is the trainee doctors who need to know to how to code for the examples provided in this guidance.Further, the RCPath guidance tends to focus on static devices (e.g., hip prosthesis), as opposed to the digital forensics of software-integrated devices, and issues of cybersecurity are not mentioned throughout the document [97].

Treatment guidelines
Applications such as MicroGuide, which is used in 91 of the 152 acute hospital trusts in the NHS in England, provide antibiotic guidelines categorised by physiological system e.g.gastro-intestinal in appendicitis [98].Technological devices are currently not a listed category under this guidance, the evidence we have presented suggests this is warranted.In addition, life support guidelines need to be adapted for device-dependant patients, highlighted by the case reports of paediatric cardiac arrests in which the non-pulsatile flow devices precluded the evaluation of pulse and blood pressure [37].

Cybersecurity & multidisciplinary solutions
Software malfunctions that put patients at risk by incorrectly over-predicting battery life present a concerning example of how software errors could prove fatal [99].The increasingly remote nature of device monitoring increases the vulnerability of these systems, evidenced in 2018 when vulnerabilities associated with the Internet connection of Medtronic programmers were exposed [99].Further cases have described the concerns of medical hacking, both in terms of individual devices but also cyberattacks on hospitals [11,22].Cyberattacks are often not understood as clinical attacks, yet to truly understand these digital threats they must be viewed through the lens of clinical consequences and as a public health risk.

Limitations
Our methodological approach is limited, by the fact it is a retrospective systematic review of heterogeneous reports, written in English, which may only reflect a small proportion of true prevalence rates in the population.In addition, by choosing to focus on individual case reports we have not covered the extent of literature that describes possible side effects of medical devices (e.g. from clinical trials) and the trends in adverse device events manifesting in the population (e.g. from the FDA MAUDE database) [100].While acknowledging that this will neglect one sub-domain of the literature, we have taken this approach in order to centre the clinical experience, which differs from existing research on device complications that is often reported by manufacturers and regulators [100].

Conclusion
New medical fields have historically emerged in response to the changing causal landscape of disease e.g., toxicology, infectious diseases.As opposed to focusing on one domain of the body, these disciplines have specialised in a mechanism of disease and become expert in how it manifests within each bodily system.We propose that a similar approach is needed for the new phenomenon of biotechnological pathology.Parts of the electromagnetic spectrum that we cannot see are potentially interacting with our internal and external environment influencing our health.Pathology may be manifesting through accidental processes that we may be blind to, malicious hacks that we may be ignorant of, or new causal pathways that we are yet to uncover.Amongst the biotechnological syndromes that were reviewed new figures appeared in the causal pathway of illness: hardware and software faults, cybersecurity exploits, microbiology of metallic implants, electromagnetic interference, connectivity complications, and sequalae relating to online experiences.These are the new processes that are now interacting with human anatomy and physiology, and they require their own clinical home to garner the exploration they urgently warrant.

Fig. 1
Fig. 1 PRISMA flow diagram for systematic reviews, which included searches of databases and registers only

Fig. 2
Fig. 2 An illustration of causal pathways to biotechnological disease, demonstrating the shared pathophysiological processes that underlie these clinical syndromes

Table 1
Number of case reports across medical specialties with an illustrative example provided in each domain

Table 2
Number of case reports across the surgical specialties, in each section a title is provided as an illustrative example

Table 3
Biotechnological case reports related to psychiatry 8 Window to His World: Using a Patient's YouTube Channel to Help Diagnose Chronic Mania 2020 9 Response patterns for individuals receiving contingent skin shock aversion intervention to treat violent self-injurious and assaultive behaviours 2021 10 Social media and smartphone technology in the symptomatology of OCD 2018 11 Adjunctive vagus nerve stimulation for treatment-resistant bipolar disorder: Managing device failure or the end of battery life 2016